Preimplantation Genetic Diagnosis & Screening in Laguna Hills, CA
Of the 15 percent of couples unable to conceive a child, genetics are implicated in at least 10 percent of those cases. For that reason, genetic testing is the new norm for parents seeking advanced fertility treatments like in-vitro fertilization (IVF). In particular, when there is a family history of genetic disorders, like cystic fibrosis, on either side of the family tree, certain types of genetic testing can determine whether you or your partner carry copies of altered genes that might put your child at risk for developing the disorder. Additionally, genetic testing prior to pregnancy can help reduce miscarriages and support a healthier pregnancy.
Presently, preimplantation genetic testing is available for embryos—prior to implantation and pregnancy—if you are undergoing the process of in-vitro fertilization. To schedule a consultation with a fertility specialist in Laguna Hills that that can perform a preimplantation genetic screening, call (949) 829-4929 or contact Dr. Angelika Priestley online.
Preimplantation Genetic Diagnosis
Preimplantation genetic diagnosis (PGD) screens single cells in each viable fertilized egg or embryo for genetic conditions and chromosomal disorders. In this way, embryos with evidence of genetic diseases are not implanted and the genetic disease can be stopped before pregnancy occurs. Prior to PGD, genetic diseases could only be detected in fetal amniotic fluid, at which point couples were faced with the choice to terminate the pregnancy. PGD, however, allows for diagnosis before the embryo is even implanted. PGD is indicated when both parents are known carriers of a genetic abnormality.
Not only can PGD screen embryos for genetic diseases like cystic fibrosis, PGD can also be used to screen embryos for their likelihood of developing certain cancers, especially for late-onset diseases like breast cancer and colon cancer.
While not elected by most parents seeking IVF, preimplantation genetic diagnosis can also be used to select gender and for HLA-matching for existing children, whereby parents can choose to give birth to a child who can be a blood and organ donor to a sick older sibling.
Some of the criteria used for determining if PGD is a recommended avenue in your in-vitro fertilization include:
- A family history of genetic disorders or diseases
- Certain ethnic backgrounds more likely to experience certain genetic conditions
Preimplantation Genetic Screening
Alternately, preimplantation genetic screening (PGS) is used with couples undergoing IVF who are not necessarily carriers of genetic abnormalities but rather have a history of multiple miscarriages and are facing severe infertility issues. PGS can isolate embryos with spontaneous chromosome abnormalities, or aneuploidy, where there is a missing or an extra chromosome, thus preventing birth defects and minimizing miscarriage rates. Preimplantation genetic screening reviews all 23 chromosomes to check for abnormalities and is accurate 90 percent of the time. PGS can greatly reduce the number of times IVF is needed to become pregnant since it is chromosomal abnormalities which typically account for up to 80 percent of implantation failures.
Some of the criteria used for determining if PGS is recommended include:
- History of repeated miscarriage
- Severe infertility issues
- Age of woman (older women are at a higher chance of experiencing chromosome abnormalities)
What to Expect from Preimplantation Genetic Testing
Your fertility specialist, as part of the in-vitro fertilization process, harvests fertilizes eggs to create viable embryos. A cell biopsy of these viable embryos is taken to undergo preimplantation genetic testing or screening. Those without genetic defect may be implanted, while the embryos in which genetic defects are seen are discarded.
If you've been suffering from infertility and are undergoing in-vitro fertilization, PGD could prevent the spread of genetic diseases further in your family tree, especially if you are a member of any of the select ethnic groups or have a family history of certain genetic diseases. If you have a history of miscarriages and seemingly intractable fertility issues, PGS might be an option for you as well in order to select the most viable embryos and carry your pregnancy to term.
Request more information about preimplantation genetic diagnosis, preimplantation genetic screening and other aspects of genetic fertility testing today. Call (949) 829-4929 or contact Dr. Angelika Priestley online.
Orange Coast Women's Medical Group
Address24411 Health Center Dr.
Laguna Hills, CA 92653
8:30 am - 5:00 pm
Tue: 8:30 am - 5:00 pm
Wed: 8:30 am - 5:00 pm
Thu: 8:30 am - 5:00 pm
Fri: 8:30 am - 5:00 pm